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Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism in patients with chronic renal failure undergoing haemodialysis.
Paricalcitol is a synthetic, biologically active vitamin D analog of calcitriol with modifications to the side chain (D2) and the A (19-nor) ring allowing for selective vitamin D receptor (VDR) activation.Paricalcitol also upregulates the calcium sensing receptor (CaSR) in the parathyroid glands.
As a result, paricalcitol reduces parathyroid hormone (PTH) levels by inhibiting parathyroid proliferation.
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